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Both the semaglutide and tirzepatide shortages that made compounding legally available were declared resolved in 2024 and 2025, the compounding wind-down deadlines have passed, and in April 2026 the FDA proposed closing the remaining legal pathway entirely

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Emerging clinical evidence supports these findings, although the underlying mechanisms remain to be fully elucidated [18,62]

For state Medicaid coverage, the price reductions will occur through supplemental rebate agreements between the state and manufacturers

No safety concern was reported (Fig 1B, left panel)

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